Endocrine Abstracts

Background: Metabolic syndrome (MS) is associated with increased mortality, and the key factors predictive of its development among patients with obesity are still unclear. We recently demonstrated with a machine learning approach that Insulin-like Growth Factor 1 (IGF-1) is a novel marker of metabolic health and that in individuals with obesity, lower IGF-1 levels are associated with increased metabolic deterioration. However, the interpretation of IGF-1 serum measurement is ...

Introduction: Lowering low-density lipoprotein cholesterol (LDL-C) via lifestyle change or pharmacologic therapy can reduce the cardiovascular risk (CV) in patients with type 2 diabetes (T2D). However, the response to lipid-lowering interventions is not uniform and a significant proportion of T2D patients do not reach the recommended LDL-C target. Elucidating the factors associated with lipid goal attainment represents an unmet clinical need.Material and...

Purpose: From a clinical perspective, the full spectrum of Sars–CoV–2–infected patients has not yet been defined. This study aimed to evaluate whether liver density on computed tomography (CT) scan and serum insulin-like growth factor 1 (IGF1) values can explain the clinical variability of COVID–19 cases.Methods: We performed a retrospective study including SARS–CoV–2–infected patients hospitalized from March 2020 to Ma...

Background and aim: Sirtuin1 (SIRT1) and sclerostin play important roles in adipose tissue and bone metabolism. SIRT1 pharmacological induction improves bone quality both in murine and human models and- as adiposity increases – its expression decreases both in peripheral tissues and blood. Sclerostin reduces osteoblasts’ differentiation and mineralization and is associated with DMT2, obesity and cardiovascular risk. We evaluated the circulating SIRT1 and sclerostin r...

Case Summary: In May 2018, a 22-year-old man was admitted to the Emergency Room of Polyclinic Umberto I Hospital of Rome, because of progressive headaches and binocular diplopia. Brain MRI revealed a heterogeneous T1WI-hypointense and T2WI-hyperintense mass of 40x28x25 mm (CC, LL, AP) including calcification areas in the left paramedian region of the clivus invading the homolateral cavernous sinus. The patient underwent partial tumour resection via infratemporal approach and a...

Background: Oxytocin (OXT) enhances glucose uptake and lipid utilization in adipose tissue and skeletal muscle.Dysfunction of the OXT system could underlie the pathogenesis of weight gain. Men and women with obesity were reported to have higher OXT blood levels compared to normal weight subjects. In contrast, metabolic syndrome has been associated with reduced fasting serum oxytocin in larger scale mixed gender studies.Aim: Data regarding the oxytocin sy...

Background: Reduced growth hormone (GH) secretory capacity is common in patients with obesity and metabolic derangements. The prevalence of GH deficiency (GHD) in this population is difficult to establish. Magnetic Resonance Imaging (MRI) pituitary findings may reflect specific endocrine alterations, as for GHD which is associated with lower pituitary height and volume (PV).Purpose: Our aim was to identify the pituitary morphological alterations predicti...